Chalcon

http://www.e-journals.net ISSN: 0973-4945; CODEN ECJHAO E-Journal of Chemistry Vol. 5, No.1, pp. 144-148, January 2008 Synthesis and Antimicrobial Activity of just closely New Chalcones of 2-Acetyl Pyridine Y. RAJENDRA PRASAD*, P. PRAVEEN KUMAR, P. RAVI KUMAR and A. SRINIVASA RAO University College of Pharmaceutical Sciences, AndhraUniversity, Visakhapatnam-530 003, (A.P), India. dryrp@rediffmail.com Received 17 July 2007; Accepted 20 September 2007 Abstract: Six new chalcones were synthesised by elicit 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR, 1H proton magnetic resonance spectroscopic data and microanalyses. The disinfectant activity of these compounds was evaluated by the transfuse plate method. Keywords: Chalcones, Synthesis, Antimicrobial activity. Introduction Chalcones either innate(p) or unreal are known to exhibit respective(a) biological activities. They pack been heralded to possess antioxidant,1-4 antimalarial,5 antileishmanial,6 antiinflammatory,7 antitumor8 and antibacterial activity9.

The front end of a excited ?,?-unsaturated keto function in chalcones is found to be responsible for their antimicrobial activity, which may be altered depending on the type and military strength of substituent on the aromatic rings. In the present communication we report the reaction of 2-acetyl pyridine with different aromatic aldehydes to form chalcones (1-6). The structures of the various synthesized compounds were assig n on the basis of elementary analyses, IR an! d 1H nuclear magnetic resonance spectral data. These compounds were also screened for their antimicrobial activity. data-based Melting points were determined on a capillary warming point apparatus and are uncorrected. 1 H NMR spectra was record in the indicated solvent on Bruker WM 400 megacycle spectrometer with TMS as internal standard. infrared frequency spectra were recorded in KBr on...If you want to get a complete essay, graze it on our website: BestEssayCheap.com

If you want to get a full essay, visit our page: cheap essay